_label-free-live-cell-imaging-mitochondria-perturbation-amp-rescue.jpg "Label-free Live Cell Imaging: Mitochondria Perturbation & Rescue from redox Video Screenshot Preview")
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⏲ Duration: 44 sec
✓ Published: 05-Sep-2018
✓ Published: 05-Sep-2018
Description:
In collaboration with Khondrion, a leading clinical-stage pharmaceutical company focusing on small molecule therapeutics for mitochondrial diseases, Nanolive images here the effect of KH176, Khondrion's leading drug candidate, in rescuing the cytotoxic effect induced by Buthionine sulfoximine (BSO). BSO inhibits the biosynthesis of glutathione, an endogenous molecule crucial for the maintenance of cellular redox states, progressively leading to cell death. KH176 counteracts BSO-induced cell deat
In collaboration with Khondrion, a leading clinical-stage pharmaceutical company focusing on small molecule therapeutics for mitochondrial diseases, Nanolive images here the effect of KH176, Khondrion's leading drug candidate, in rescuing the cytotoxic effect induced by Buthionine sulfoximine (BSO). BSO inhibits the biosynthesis of glutathione, an endogenous molecule crucial for the maintenance of cellular redox states, progressively leading to cell death. KH176 counteracts BSO-induced cell deat
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